What is he wants nothing to do with me?

As an AI language model, I do not have any prior knowledge of any person or situation. However, generally, the statement "he wants nothing to do with me" implies that the person in question has no interest in communicating or having any sort of interaction with the speaker. This can be due to various reasons, such as a conflict or disagreement, lack of interest or emotional distance. It is best to communicate openly and honestly to address the situation and understand the reason behind the person's behavior.